I've seen this again this morning - the issue actually appears after you restart the SMTP service - which of course happens on a system restart. I've found nothing on the internet that refers to this yet.
For the moment I am considering setting up a timed task to restart the service once or twice a day e.g. 12:00 and 00:00.
The SolarWinds monitor, while it is useful, doesn't show any light on this issue since it doesn't see the messages until the service is restarted.
Edit: I found a couple of links that might be of use:
http://technet.microsoft.com/en-us/library/aa998772.aspx
http://forums.msrportal.com/showthread.php?t=22181
so I've made the GlitchRetry change and set the SMTP service to restart twice a day: lets see what happens...
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