Backups have been failing for some time (for which I have another thread, still ongoing) but now it's just got really serious...

The Microsoft Exchange MTA Stacks service won't start, although I'm not sure that's too serious, but I have found the following event logs which seem to be;
______________________
Event Type: Warning
Event Source: W3SVC
Event Category: None
Event ID: 101
Date: 04/07/2008
Time: 10:52:37
User: N/A
Computer: SERVER
Description:
The server was unable to add the virtual root '/public' for the directory 'M:\ domain-name.co.uk\Public Folders' due to the following error: The system cannot find the path specified. The data is the error code.
For additional information specific to this message please visit the Microsoft Online Support site located at: http://www.microsoft.com/contentredirect.asp.
Data:
0000: 03 00 00 00 ....
______________________
Event Type: Warning
Event Source: W3SVC
Event Category: None
Event ID: 101
Date: 04/07/2008
Time: 10:52:37
User: N/A
Computer: SERVER
Description:
The server was unable to add the virtual root '/Exchange' for the directory 'M:\ domain-name.co.uk\MBX' due to the following error: The system cannot find the path specified. The data is the error code.
For additional information specific to this message please visit the Microsoft Online Support site located at: http://www.microsoft.com/contentredirect.asp.
Data:
0000: 03 00 00 00 ....
______________________
Event Type: Warning
Event Source: W3SVC
Event Category: None
Event ID: 101
Date: 04/07/2008
Time: 10:52:37
User: N/A
Computer: SERVER
Description:
The server was unable to add the virtual root '/Exadmin' for the directory '\\.\BackOfficeStorage' due to the following error: The system cannot find the path specified. The data is the error code.
For additional information specific to this message please visit the Microsoft Online Support site located at: http://www.microsoft.com/contentredirect.asp.
Data:
0000: 03 00 00 00 ....
______________________
Event Type: Error
Event Source: MSExchangeSA
Event Category: MAPI Session
Event ID: 9175
Date: 04/07/2008
Time: 12:05:24
User: N/A
Computer: SERVER
Description:
The MAPI call 'OpenMsgStore' failed with the following error:
The attempt to log on to the Microsoft Exchange Server computer has failed.
The MAPI provider failed.
Microsoft Exchange Server Information Store
ID no: 8004011d-0512-00000000
I'm not sure whether this is a standard set up (as I'm not an Exchange admin) but everything exchange seems to point to the M: partition which now appears to be empty (I'm sure it never used to be).
I'm utterly and completely stuck and urgently need help with this - my neck is well and truly on the line!
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